Karen K. Smith-McCune, MD, PhD
- John Kerner Endowed Professor of
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|Mailing Address:||2340 Sutter St., Rm S-229
San Francisco, CA 94143-0128
Dr. Karen K. Smith-McCune is the John Kerner Endowed Professor in Gynecologic Oncology in the Department of Obstetrics, Gynecology and Reproductive Sciences and is the director of the Dysplasia Clinic at the UCSF Helen Diller Family Comprehensive Cancer Center. Her research interests are focused in abnormal pap smears, cervical pre-cancer, cervical cancer screening, Human Papilloma Virus (HPV) and vulvar disease. One of her main goals is to identify drugs that merit clinical testing for treatment of cervical dysplasia or cancer as well as to improve tests used by clinicians to quickly and accurately distinguish low-grade cervical dysplasias from high-grade ones. She is also one of the principal investigators on a project in Zimbabwe examining a barrier contraceptive and HPV acquisition. Her research involving gynecologic malignancies and dysplasia has been published in journals such as the New England Journal of Medicine and the American Journal of Obstetrics and Gynecology, as well as others.
|Year||Institution & Location||Degree||Field of Study|
|1975||McGill University, Montreal, Quebec, Canada||BSc||Biochemistry|
|1976||University of Cambridge, London, UK||Diploma||History & Philosophy of Science|
|1982||Rockefeller University, New York||PhD||Biological Chemistry|
|1986||Stanford University, Stanford, CA||MD||Medicine|
|1990||University of California, San Francisco||Internship & Residency||Obstetrics & Gynecology|
Achievements & Recognition
|1987||Julius R. Krevans Award for Clinical Excellence, UCSF|
|1998||ASCCP Colposcopy Recognition Award|
|1998||John Kerner Endowed Chair of Gynecologic Oncology|
|2006||Award of Merit, American Society of Colposcopy and Cervical Pathology|
Selected Recent Publications
Nanjundan M, Zhang F, 33. Schmandt R, Smith-McCune K, and Mills GB. Identification of a novel splice variant of AML1b in ovarian cancer patients conferring loss of wild-type tumor suppressive functions. Oncogene 2007:26:2574-84.
Nanjundan M, Nakayama Y, Cheng KW, Lahad J, Liu J, Lu K, Kuo WL, Smith-McCune K, Fishman D, Gray JW, Mills GB. Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer. Cancer Res. 2007;67(7):3074-84.
Nanjundan M, Zhang F, Schmandt R, Smith-McCune K, and Mills GB. Identification of a novel splice variant of AML1b in ovarian cancer patients conferring loss of wild-type tumor suppressive functions. Oncogene. 2007:26:2574-84.
Sawaya GF, Smith-McCune K. HPV vaccination--more answers, more questions. N Engl J Med. 2007:10;356(19):1991-3.
McCune, KS. Risk-based, postcolposcopic surveillance and management for HC2+ ASC and LSIL. Am J Obstet Gynecol. 2007:196(5):e58.
Kobayashi A, Weinberg V, Darragh T, Smith-McCune K. Evolving immunosuppressive microenvironment during human cervical carcinogenesis. Mucosal Immunol. July 2008 epub: 10.1038/mi.2008.33.
Sawaya GF, Chirenje MZ, Magure MT, Tuveson JL, Ma Y, Shiboski SC, Da Costa MM, Palefsky JM, Moscicki AB, Mutasa RM, Chipato T, Smith-McCune KK. Effect of diaphragm and lubricant gel provision on human papillomavirus infection among women provided with condoms: a randomized controlled trial. Obstet Gynecol. 2008 Nov;112(5):990-7.
Fukuchi E, Sawaya GF, Chirenje M, Magure T, Tuveson J, Ma Y, Shiboski S, Da Costa M, Palefsky J, Moscicki AB, Makunike-Mutasa R, Chipato T, Smith-McCune KK.Cervical human papillomavirus incidence and persistence in a cohort of HIV-negative women in Zimbabwe. Sex Transm Dis. 2009 May;36(5):305-11.
Smith-McCune K, Shiboski S, Chirenje ZM, Magure T, Tuveson J, Ma Y, DaCosta M, Moscicki AB, Palefsky J, Makunike-Mutasa J, Chipato T, van der Straten A, Sawaya GF. Type-specific Cervico-Vaginal Human Papillomavirus Infection Increases Risk of HIV Acquisition Independent of Other Sexually Transmitted Infections. PLoS ONE 2009:e10094, PMID: 20386706.
Smith-McCune K, Sawaya GF. Update on quadrivalent human papillomavirus vaccination and pregnancy outcomes: Is contraception advisable? Obstet Gynecol. 2009 Dec;114(6):1168-9. PMID: 19935015
Ishida S, McCormick F, Smith-McCune K, Hanahan D. Enhancing Tumor-Specific Uptake of the Anticancer Drug Cisplatin with a Copper Chelator. Cancer Cell 2010;17(6):574-583. PMID: 20541702
Hennessy BT, Timms KM, Carey MS, Gutin A, Meyer LA, Flake DD 2nd, Abkevich V, Potter J, Pruss D, Glenn P, Li Y, Li J, Gonzalez-Angulo AM, McCune KS, Markman M, Broaddus RR, Lanchbury JS, Lu KH, Mills G. Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer. J Clin Oncol. 2010;28(22):3570-6. PMID: 20606085
Partridge EE, Abu-Rustum NR, Campos SM, Fahey PJ, Farmer M, Garcia RL, Giuliano A, Jones HW 3rd, Lele SM, Lieberman RW, Massad SL, Morgan MA, Reynolds RK, Rhodes HE, Singh DK, Smith-McCune K, Teng N, Trimble CL, Valea F, Wilczynski S. Cervical cancer screening. J Natl Compr Canc Netw. 2010;8(12):1358-86. PMID: 21147902